BAY 299 ( BAY299 )

Catalog No. M13241 CAS No. 2080306-23-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BAY 299
Note

Research use only, not for human use.
Brief Description

BAY 299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 and the second bromodomain of TAF1 with IC50 of 6 nM and 13 nM, respectively.
Description

BAY 299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 and the second bromodomain of TAF1 with IC50 of 6 nM and 13 nM, respectively; dispalys >30-fold selective over BRPF1, BRPF3, BRD9, and ATAD2 and is >300-fold selective over BRD4.
Synonyms

BAY299
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

2080306-23-4
Formula Weight

429.48
Molecular Formula

C25H23N3O4
Purity

>98% (HPLC)
Solubility

DMSO : 25 mg/mL 58.21 mM
SMILES

O=C1N(C2=C(C)C=C(N3C)C(N(C)C3=O)=C2)C(C4=CC=C(CCCO)C5=CC=CC1=C45)=O
Chemical Name

2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3(2H)-dione

1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

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